The building, which previously housed the Oriental Yard restaurant, is located at the intersection of Olhiyivska and Mechnykov Streets.
The State Emergency Situations Service reported there were no casualties, Odesa news portal dumskaya.net wrote.
According to unconfirmed reports, the explosion damaged a gas pipe, but the emergencies service prevented its detonation.
Hromadske.tv reported that the explosion occurred at 2224 Kyiv time on Saturday. Unconfirmed reports said that a public organization was located there.