REUTERS

Kerry has pointedly avoided new bilateral negotiations with Lavrov, and his invitation to the Turkish, Saudi, Qatari and Iranian foreign ministers to join them for talks in the Swiss lakeside town of Lausanne will broaden the discussion to include the most powerful backers of Syria's government and rebels, as reported by Reuters.

"I don't know that I would expect any breakthroughs. I would just say that we're working to get this multilateral effort and approach to Syria up and running," U.S. State Department spokesman Mark Toner told reporters in Washington.

Read alsoWSJ: Europe's ties with Russia fray in face of Moscow's role in Aleppo bombingPressure is rising for a halt to a ferocious, three-week-old Syrian government offensive to capture the rebel-held eastern zone of the city of Aleppo, where the United Nations says 275,000 civilians still live and 8,000 rebels are holding out against Syrian, Russian and Iranian-backed forces.

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Western powers have accused Russia and Syria of committing atrocities by bombing hospitals, killing civilians and preventing medical evacuations, as well as targeting an aid convoy with the loss of around 20 lives.

Syria and Russia counter that they only targeting militants in Aleppo and accuse the United States of breaking the ceasefire by bombing scores of Syrian troops fighting Islamic State insurgents, over which the United States has expressed "regret."