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A confidential October 29 report by the Organization for the Prohibition of Chemical Weapons (OPCW), a summary of which was shown to Reuters, concluded "with the utmost confidence that at least two people were exposed to sulfur mustard" in the town of Marea, north of Aleppo, on August 21.

"It is very likely that the effects of sulfur mustard resulted in the death of a baby," it said.

The findings provide the first official confirmation of use of sulfur mustard, commonly known as mustard gas, in Syria since it agreed to destroy its chemical weapons stockpile, which included sulfur mustard.

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The report did not mention Islamic State, as the fact-finding mission was not mandated to assign blame, but diplomatic sources said the chemical had been used in the clashes between Islamic State and another rebel group taking place in the town at the time.

"It raises the major question of where the sulfur mustard came from," one source said. "Either they (IS) gained the ability to make it themselves, or it may have come from an undeclared stockpile overtaken by IS. Both are worrying options."

Syria is supposed to have completely surrendered the toxic chemicals 18 months ago. Their use violates U.N. Security Council resolutions and the 1997 Chemical Weapons Convention.

In a statement to Reuters, State Department spokesman John Kirby said the OPCW released three reports to member states on October 29, adding "two of these reports are very disturbing. The OPCW has confirmed (chemical weapons) use in one investigation, and concluded likely use in a second."

In addition to the incident involving the mustard agent, Kirby said, the OPCW confirmed that toxic chemicals, probably containing chlorine, were used in opposition-controlled territory in Idlib Province.

"Witnesses reported hearing helicopters overhead at the time the chemical munitions exploded. Only the Assad regime has helicopters," he said, referring to President Bashar al-Assad's government.

The reports, which will be formally presented to U.N. Secretary General Ban Ki-moon later this month, add to a growing body of evidence that the Islamic State group has obtained, and is using, chemical weapons in both Iraq and Syria.

"If it is determined that a non-state actor such as ISIL was also using chemical weapons, such use would be consistent with ISIL's record of complete disregard for human rights and international norms and values," Kirby said, using an alternate acronym for Islamic State.

Kurdish authorities said earlier this month that Islamic State fighters fired mortar rounds containing mustard agent at Kurdish peshmerga fighters in northern Iraq during clashes in August. They said blood samples taken from about 35 fighters who were exposed in the attack southwest of the regional capital of Erbil showed "signatures" of mustard gas.

Syria agreed in September 2013 to destroy its entire chemical weapons program under a deal negotiated with the United States and Russia after hundreds of people were killed in a sarin gas attack in the outskirts of the capital, Damascus.

The last of 1,300 tonnes of chemical weapons declared to the OPCW was handed over in June 2014, but several Western governments have expressed doubt that Assad's government declared its entire arsenal.