"The EU referendum is the biggest democratic decision of our time, and will have far-reaching consequences for generations to come," the letter says, The Telegraph reports.

"The referendum forces us to look in the mirror and ask ourselves: what kind of nation do we want to be? Are we outward-looking and open to working with others to achieve more? Or do we close ourselves off from our friends and neighbors at a time of increasing global uncertainty?"

Read alsoDavid Cameron: ISIS, Vladimir Putin 'might be happy' with Brexit"From the smallest gallery to the biggest blockbuster, many of us have worked on projects that would never have happened without EU funding or collaborating across borders. Britain is not just stronger in the EU, it is more imaginative and creative. Our global creative success would be severely weakened by walking away," the letter reads.